Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.

ABSTRACT:

Background

Neuregulin-1 (NRG1) gene polymorphisms have been proposed as risk factors for several common disorders. Associations with cognitive variation have also been tested. With regard to schizophrenia (SZ) risk, studies of Caucasian ancestry samples indicate associations more consistently than East Asian samples, suggesting heterogeneity. To exploit the differences in linkage disequilibrium (LD) structure across ethnic groups, we conducted a SZ case-control study (that included cognitive evaluations) in a sample from the north Indian population.

Methods

NRG1 variants (n=35 SNPs, three microsatellite markers) were initially analyzed among cases (DSM IV criteria, n=1007) and controls (n=1019, drawn from two groups) who were drawn from the same geographical region in North

SUBMITTER: Kukshal P 

PROVIDER: S-EPMC4040109 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature