Effect of sequence features on assembly of spider silk block copolymers.

ABSTRACT: Bioengineered spider silk block copolymers were studied to understand the effect of protein chain length and sequence chemistry on the formation of secondary structure and materials assembly. Using a combination of in vitro protein design and assembly studies, we demonstrate that silk block copolymers possessing multiple repetitive units self-assemble into lamellar microstructures. Additionally, the study provides insights into the assembly behavior of spider silk block copolymers in concentrated salt solutions.

SUBMITTER: Tokareva OS 

PROVIDER: S-EPMC4040161 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature