Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor.

ABSTRACT: The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the "bottom-up" design of a small molecule inhibitor of oncogenic microRNA-10b.

SUBMITTER: Velagapudi SP 

PROVIDER: S-EPMC4040211 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature