Identifying large-scale brain networks in fragile X syndrome.

ABSTRACT:

Importance

Fragile X syndrome (FXS) is an X-linked neurogenetic disorder characterized by a cognitive and behavioral phenotype resembling features of autism spectrum disorder. Until now, research has focused largely on identifying regional differences in brain structure and function between individuals with FXS and various control groups. Very little is known about the large-scale brain networks that may underlie the cognitive and behavioral symptoms of FXS.

Objective

To identify large-scale, resting-state networks in FXS that differ from control individuals matched on age, IQ, and severity of behavioral and cognitive symptoms.

Design, setting, and participants

Cross-sectional, in vivo neuroimaging study conducted in an academic medical center. Participants (aged 10-2

SUBMITTER: Hall SS 

PROVIDER: S-EPMC4040266 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature