Project description:Allergic transfusion reactions (ATRs) occur within 24 h of transfusion. A less common but more severe manifestation of ATR is anaphylaxis. The relationship between the mechanisms underlying ATRs and donor, product, and/or recipient factors is not well understood. Our aim is to investigate the underlying factors responsible for eliciting anaphylactic ATRs and possibly identify the molecule responsible, that could routinely be used as a biomarker in subsequent pre-transfusion screens. We employ an IP-MS workflow for this purpose. Purified IgG antibodies from donor plasma are immobilized on magnetic beads and interacted with basophil cells lysates. The immunoprecipitants are analyzed by mass spectrometry.

2026-06-08 | PXD045721 | Pride

Relationship between allergic sensitisation-associated single-nucleotide polymorphisms and allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric cases.

Project description: Not available

| S-EPMC8971021 | biostudies-literature

Differentiating pulmonary transfusion reactions using recipient and transfusion factors.

Project description: Not available

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Identification of new bioactive molecules in platelet preparation, storage, and transfusion reactions for improved transfusion management.

Project description: Not available

| S-EPMC11599570 | biostudies-literature

Data from differentially expressed proteins in platelet components associated with adverse transfusion reactions.

Project description: Not available