Ontology highlight
ABSTRACT:
SUBMITTER: Schreiber SN
PROVIDER: S-EPMC404069 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Schreiber Sylvia N SN Emter Roger R Hock M Benjamin MB Knutti Darko D Cardenas Jessica J Podvinec Michael M Oakeley Edward J EJ Kralli Anastasia A
Proceedings of the National Academy of Sciences of the United States of America 20040415 17
Estrogen-related receptor alpha (ERRalpha) is one of the first orphan nuclear receptors to be identified, yet its physiological functions are still unclear. We show here that ERRalpha is an effector of the transcriptional coactivator PGC-1alpha [peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha], and that it regulates the expression of genes involved in oxidative phosphorylation and mitochondrial biogenesis. Inhibition of ERRalpha compromises the ability of PGC-1alp ...[more]