Clinical and genetic factors predicting response to therapy in patients with Crohn's disease.

ABSTRACT:

Aim

To identify clinical and/or genetic predictors of response to several therapies in Crohn's disease (CD) patients.

Methods

We included 242 patients with CD (133 females) aged (mean ± standard deviation) 39 ± 12 years and a disease duration of 12 ± 8 years. The single-nucleotide polymorphisms (SNPs) studied were ABCB1 C3435T and G2677T/A, IL23R G1142A, C2370A, and G9T, CASP9 C93T, Fas G670A and LgC844T, and ATG16L1 A898G. Genotyping was performed with real-time PCR with Taqman probes.

Results

Older patients responded better to 5-aminosalicylic acid (5-ASA) and to azathioprine (OR 1.07, p = 0.003 and OR 1.03, p = 0.01, respectively) while younger ones responded better to biologicals (OR 0.95, p = 0.06). Previous surgery negatively influenced response to 5-ASA compoun

SUBMITTER: Cravo M 

PROVIDER: S-EPMC4040806 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature