Rapid air infusion into the oesophagus: Motor response in patients with achalasia and nonobstructive dysphagia assessed with high-resolution manometry.

ABSTRACT:

Background

Achalasia is a neurodegenerative disorder of the oesophagus. Alteration of motor activity induced by oesophageal distension has not been explored.

Objectives

To investigate this function, using high-resolution Manometry.

Methods

This study enrolled 15 healthy subjects, 15 nonobstructive dysphagia (NOD), and 18 achalasia patients successfully treated with pneumatic dilation (six with restored peristalsis). The three groups underwent five rapid (<1 s) intraoesophageal infusions of 20-ml air boluses, followed by eight 5-ml water swallows.

Results

WHEREAS THE RESPONSE RATE TO WATER SWALLOWS WAS SIMILAR IN THE THREE GROUPS, AIR INFUSION INDUCED A LOWER RESPONSE RATE IN ACHALASIA (MEDIAN, INTERQUARTILE RANGE: 70%, 40-100%) and, to a lesser extent, in NOD p

SUBMITTER: Elvevi A 

PROVIDER: S-EPMC4040817 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature