Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes.

ABSTRACT: The complete set of viable deletion strains in Saccharomyces cerevisiae was screened for sensitivity of mutants to five oxidants to identify cell functions involved in resistance to oxidative stress. This screen identified a unique set of mainly constitutive functions providing the first line of defense against a particular oxidant; these functions are very dependent on the nature of the oxidant. Most of these functions are distinct from those involved in repair and recovery from damage, which are generally induced in response to stress, because there was little correlation between mutant sensitivity and the reported transcriptional response to oxidants of the relevant gene. The screen identified 456 mutants sensitive to at least one of five different types of oxidant, and these were ranke

SUBMITTER: Thorpe GW 

PROVIDER: S-EPMC404085 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature