Genome comparison of Candida orthopsilosis clinical strains reveals the existence of hybrids between two distinct subspecies.

ABSTRACT: The Candida parapsilosis species complex comprises a group of emerging human pathogens of varying virulence. This complex was recently subdivided into three different species: C. parapsilosis sensu stricto, C. metapsilosis, and C. orthopsilosis. Within the latter, at least two clearly distinct subspecies seem to be present among clinical isolates (Type 1 and Type 2). To gain insight into the genomic differences between these subspecies, we undertook the sequencing of a clinical isolate classified as Type 1 and compared it with the available sequence of a Type 2 clinical strain. Unexpectedly, the analysis of the newly sequenced strain revealed a highly heterozygous genome, which we show to be the consequence of a hybridization event between both identified subspecies. This implicitly sugges

SUBMITTER: Pryszcz LP 

PROVIDER: S-EPMC4040990 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature