The NQO1 Pro187Ser polymorphism and breast cancer susceptibility: evidence from an updated meta-analysis.

ABSTRACT:

Background nad(p)h

quinone oxidoreductase 1 (NQO1) plays a central role in catalyzing the two-electron reduction of quinoid compounds into hydroquinones. The NQO1 Pro187Ser polymorphism was found to correlate with a lower enzymatic activity, which may result in increased incidence of carcinomas including breast cancer. Previous studies investigating the association between NQO1 Pro187Ser polymorphism and breast cancer risk showed inconsistent results. We performed a meta-analysis to summarize the possible association.

Methods

All studies published from January 1966 to February 2014 on the association between NQO1 Pro187Ser polymorphism and breast cancer risk were identified by searching electronic databases PubMed, EMBASE, Cochrane library, and Chinese Biomedical Literature

SUBMITTER: Peng Q 

PROVIDER: S-EPMC4041044 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature