A modular minimal cell model: purine and pyrimidine transport and metabolism.

ABSTRACT: A more complete understanding of the relationship of cell physiology to genomic structure is desirable. Because of the intrinsic complexity of biological organisms, only the simplest cells will allow complete definition of all components and their interactions. The theoretical and experimental construction of a minimal cell has been suggested as a tool to develop such an understanding. Our ultimate goal is to convert a "coarse-grain" lumped parameter computer model of Escherichia coli into a genetically and chemically detailed model of a "minimal cell." The base E. coli model has been converted into a generalized model of a heterotrophic bacterium. This coarse-grain minimal cell model is functionally complete, with growth rate, composition, division, and changes in cell morphology as natur

SUBMITTER: Castellanos M 

PROVIDER: S-EPMC404105 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature