Sleep and movement differentiates actions of two types of somatostatin-expressing GABAergic interneuron in rat hippocampus.

ABSTRACT: Neuropeptides acting on pre- and postsynaptic receptors are coreleased with GABA by interneurons including bistratified and O-LM cells, both expressing somatostatin but innervating segregated dendritic domains of pyramidal cells. Neuropeptide release requires high-frequency action potentials, but the firing patterns of most peptide/GABA-releasing interneurons during behavior are unknown. We show that behavioral and network states differentiate the activities of bistratified and O-LM cells in freely moving rats. Bistratified cells fire at higher rates during sleep than O-LM cells and, unlike O-LM cells, strongly increase spiking during sharp wave-associated ripples (SWRs). In contrast, O-LM interneurons decrease firing during sleep relative to awake states and are mostly inhibited during SW

SUBMITTER: Katona L 

PROVIDER: S-EPMC4041064 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature