SALL4 expression in germ cell and non-germ cell tumors: a systematic immunohistochemical study of 3215 cases.

ABSTRACT: The SALL4 transcription factor is associated with embryonic cell pluripotency and has been shown as a useful immunohistochemical marker for germ cell tumors. However, information of SALL4 distribution in normal human tissues and non-germ cell tumors is limited. In this study we examined normal human tissues and 3215 tumors for SALL4 expression using a monoclonal antibody 6E3 and automated immunohistochemistry. In a 10-week embryo, SALL4 was expressed in ovocytes, intestine, kidney, and some hepatocytes. In adult tissues, it was only detected in germ cells. SALL4 was consistently expressed in all germ cell tumors except some trophoblastic tumors and mature components of teratomas, in which it was selectively expressed in intestinal-like and some squamous epithelia. In non-germ cell carcinom

SUBMITTER: Miettinen M 

PROVIDER: S-EPMC4041084 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature