APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD. We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio and per cent emphysema. We identified one new polymorphism for FEV1/FVC (rs805301) in European-Ame

SUBMITTER: Burkart KM 

PROVIDER: S-EPMC4041087 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature