Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population.

ABSTRACT:

Purpose

To replicate previously confirmed telomere-length loci in a Chinese Han population with coronary heart disease (CHD), and investigate these loci and the possibility of and age at onset of CHD.

Patients and methods

1514 CHD patients and 2470 normal controls were recruited. Medical data including age, sex, body mass index, lipid profiles, history of hypertension, type 2 diabetes mellitus, and dyslipidemia were collected from all the participants. Seven previously identified single-nucleotide polymorphisms (SNPs) related to leucocyte telomere length were genotyped, including rs10936599 in TERC, rs2736100 in TERT, rs7675998 in NAF1, rs9420907 in OBFC1, rs8105767 in ZNF208, rs755017 in RTEL1, and rs11125529 in ACYP2.

Results

No significant difference in genotype fr

SUBMITTER: Ding H 

PROVIDER: S-EPMC4041376 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature