Revisiting schizophrenia linkage data in the NIMH Repository: reanalysis of regularized data across multiple studies.

ABSTRACT:

Objective

The Combined Analysis of Psychiatric Studies (CAPS) project conducted extensive review and regularization across studies of all schizophrenia linkage data available as of 2011 from the National Institute of Mental Health-funded Center for Collaborative Genomic Studies on Mental Disorders, also known as the Human Genetics Initiative (HGI). The authors reanalyzed the data using statistical methods tailored to accumulation of evidence across multiple, potentially highly heterogeneous, sets of data.

Method

Data were subdivided based on contributing study, major population group, and presence or absence within families of schizophrenia with a substantial affective component. The posterior probability of linkage (PPL) statistical framework was used to sequentially update

SUBMITTER: Vieland VJ 

PROVIDER: S-EPMC4041610 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature