Discordance in hormone receptor status among primary, metastatic, and second primary breast cancers: biological difference or misclassification?

ABSTRACT:

Introduction

Discordance in hormone receptor status has been observed between two breast tumors of the same patients; however, the degree of heterogeneity is debatable with regard to whether it reflects true biological difference or the limited accuracy of receptor assays.

Methods

A Bayesian misclassification correction method was applied to data on hormone receptor status of two primary breast cancers from the Surveillance, Epidemiology, and End Results database between 1990 and 2010 and to data on primary breast cancer and paired recurrent/metastatic disease assembled from a meta-analysis of the literature published between 1979 and 2014.

Results

The sensitivity and specificity of the estrogen receptor (ER) assay were estimated to be 0.971 and 0.920, respectively. A

SUBMITTER: Sighoko D 

PROVIDER: S-EPMC4041672 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature