Differential expression of microRNA and predicted targets in pulmonary sarcoidosis.

ABSTRACT:

Background

Recent studies show that various inflammatory diseases are regulated at the level of RNA translation by small non-coding RNAs, termed microRNAs (miRNAs). We sought to determine whether sarcoidosis tissues harbor a distinct pattern of miRNA expression and then considered their potential molecular targets.

Methods and results

Genome-wide microarray analysis of miRNA expression in lung tissue and peripheral blood mononuclear cells (PBMCs) was performed and differentially expressed (DE)-miRNAs were then validated by real-time PCR. A distinct pattern of DE-miRNA expression was identified in both lung tissue and PBMCs of sarcoidosis patients. A subgroup of DE-miRNAs common to lung and lymph node tissues were predicted to target transforming growth factor (TGFβ)-regulate

SUBMITTER: Crouser ED 

PROVIDER: S-EPMC4041713 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature