Delirium and high fever are associated with subacute motor deterioration in Parkinson disease: a nested case-control study.

ABSTRACT:

Background

In Parkinson disease (PD), systemic inflammation caused by respiratory infections such as pneumonia frequently occurs, often resulting in delirium in the advanced stages of this disease. Delirium can lead to cognitive and functional decline, institutionalization, and mortality, especially in the elderly. Inflammation causes rapid worsening of PD motor symptoms and signs, sometimes irreversibly in some, but not all, patients.

Purpose

To identify factors associated with subacute motor deterioration in PD patients with systemic inflammation.

Methods

The association of clinical factors with subacute motor deterioration was analyzed by a case-control study. Subacute motor deterioration was defined as sustained worsening by one or more modified Hoehn and Yahr (H-

SUBMITTER: Umemura A 

PROVIDER: S-EPMC4041721 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature