Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN.

ABSTRACT:

Background

Dengue Virus (DENV) is the most common mosquito-borne viral infection worldwide. Important target cells during DENV infection are macrophages, monocytes, and immature dendritic cells (imDCs). DENV-infected cells are known to secrete a large number of partially immature and fully immature particles alongside mature virions. Fully immature DENV particles are considered non-infectious, but antibodies have been shown to rescue their infectious properties. This suggests that immature DENV particles only contribute to the viral load observed in patients with a heterologous DENV re-infection.

Methodology/principal findings

In this study, we re-evaluated the infectious properties of fully immature particles in absence and presence of anti-DENV human serum. We show that im

SUBMITTER: Richter MK 

PROVIDER: S-EPMC4041791 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature