Serum brain natriuretic peptide and risk of acute kidney injury after cardiac operations in children.

ABSTRACT:

Background

Acute kidney injury (AKI) after pediatric cardiac operations is associated with poor outcomes and is difficult to predict. We conducted a prospective study to evaluate whether preoperative brain natriuretic peptide (BNP) levels predict postoperative AKI among children undergoing cardiac operations.

Methods

This was a three-center, prospective study (2007-2009) of 277 children undergoing cardiac operations (n = 121, aged <2 years) with available preoperative BNP values. Preoperative BNP was measured and categorized into tertiles. The performance of BNP was evaluated alone and in combination with clinical factors. AKI was defined as doubling of serum creatinine or need for acute dialysis.

Results

Postoperative AKI occurred in 165 children (60%), with 118 case

SUBMITTER: Hornik CP 

PROVIDER: S-EPMC4041833 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature