Soluble CD163 as a marker of macrophage activity in newly diagnosed patients with multiple sclerosis.

ABSTRACT:

Background

Soluble CD163 (sCD163) is a macrophage specific protein known to be up-regulated in serum from patients with multiple sclerosis (MS).

Objective

To investigate sCD163 in serum and CSF (cerebrospinal fluid) from patients undergoing MS diagnostic work-up and analyse its potential as a diagnostic biomarker.

Methods

After a full MS diagnostic work-up, including collection of paired samples of CSF and serum, 183 patients were evaluated for inclusion in this study. Patients were divided into groups based on their diagnosis. Patients with normal clinical and paraclinical findings were grouped as symptomatic controls. Serum and CSF levels of sCD163 were determined by enzyme-linked immunosorbent assay (ELISA).

Results

sCD163 could be measured in all serum and

SUBMITTER: Stilund M 

PROVIDER: S-EPMC4041861 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature