Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research.

ABSTRACT:

Background

The DA rat strain is particularly susceptible to the induction of a number of chronic inflammatory diseases, such as models for rheumatoid arthritis and multiple sclerosis. Here we sequenced the genomes of two DA sub-strains and two disease resistant strains, E3 and PVG, previously used together with DA strains in genetically segregating crosses.

Results

The data uncovers genomic variations, such as single nucleotide variations (SNVs) and copy number variations that underlie phenotypic differences between the strains. Comparisons of regional differences between the two DA sub-strains identified 8 genomic regions that discriminate between the strains that together cover 38 Mbp and harbor 302 genes. We analyzed 10 fine-mapped quantitative trait loci and our data imp

SUBMITTER: Backdahl L 

PROVIDER: S-EPMC4041999 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature