Arg389Gly β1-adrenergic receptor polymorphism and susceptibility to syncope during tilt test.

ABSTRACT:

Introduction

Numerous hormones, neurotransmitters, and other stimuli exert their biological effect on cellular functioning through heptahelical receptors coupled to G proteins (GPCR - G protein-coupled receptors). Adrenergic receptors that belong to this superfamily of receptors are components of the sympathetic nervous system. They play a pivotal role in blood pressure regulation and myocardial contractility. Alterations of the adrenergic receptor pathway have been suggested to be involved in the pathophysiology of vasovagal syncope (VVS). The aim of the present study was to evaluate the distribution of Arg389Gly polymorphism within the ADRB1 gene among patients with recurrent syncope.

Material and methods

Arg389Gly single nucleotide polymorphism was analyzed in 205 patient

SUBMITTER: Zelazowska M 

PROVIDER: S-EPMC4042044 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature