Naloxone therapy in opioid overdose patients: intranasal or intravenous? A randomized clinical trial.

ABSTRACT:

Introduction

This study was designed to compare the effects of intranasal (IN) and intravenous (IV) administration of naloxone in patients who had overdosed on opioids.

Material and methods

This randomized clinical trial study was conducted in the Department of Poisoning Emergencies at Noor and Ali Asghar (PBUH) University Hospital. One hundred opioid overdose patients were assigned by random allocation software into two study groups (n = 50). Both groups received 0.4 mg naloxone: one group IN and the other IV. Outcomes included change in the level of consciousness (measured using a descriptive scale and the Glasgow Coma Scale (GCS)), time to response, vital signs (blood pressure, heart rate and respiratory rate), arterial blood O2 saturation before and after naloxone admini

SUBMITTER: Sabzghabaee AM 

PROVIDER: S-EPMC4042052 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature