Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels.

ABSTRACT: Openings of high-voltage-activated (HVA) calcium channels lead to a transient increase in calcium concentration that in turn activate a plethora of cellular functions, including muscle contraction, secretion and gene transcription. To coordinate all these responses calcium channels form supramolecular assemblies containing effectors and regulatory proteins that couple calcium influx to the downstream signal cascades and to feedback elements. According to the original biochemical characterization of skeletal muscle Dihydropyridine receptors, HVA calcium channels are multi-subunit protein complexes consisting of a pore-forming subunit (α1) associated with four additional polypeptide chains β, α2, δ, and γ, often referred to as accessory subunits. Twenty-five years after the first purificatio

SUBMITTER: Neely A 

PROVIDER: S-EPMC4042065 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature