Recognizing methylated histone variant H3.3 to prevent tumors.

ABSTRACT: Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors.

SUBMITTER: Venkatesh S 

PROVIDER: S-EPMC4042173 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature