Metabolic changes associated with the long winter fast dominate the liver proteome in 13-lined ground squirrels.

ABSTRACT: Small-bodied hibernators partition the year between active homeothermy and hibernating heterothermy accompanied by fasting. To define molecular events underlying hibernation that are both dependent and independent of fasting, we analyzed the liver proteome among two active and four hibernation states in 13-lined ground squirrels. We also examined fall animals transitioning between fed homeothermy and fasting heterothermy. Significantly enriched pathways differing between activity and hibernation were biased toward metabolic enzymes, concordant with the fuel shifts accompanying fasting physiology. Although metabolic reprogramming to support fasting dominated these data, arousing (rewarming) animals had the most distinct proteome among the hibernation states. Instead of a dominant metabolic

SUBMITTER: Hindle AG 

PROVIDER: S-EPMC4042184 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature