In utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate promotes local adipose and systemic inflammation in adult male offspring.

ABSTRACT:

Background

Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer used to increase the flexibility of polyvinyl chloride. DEHP and its active metabolite mono-(2-ethylhexyl) phthalate are detected in many biological fluids during fetal and postnatal life. In rodent models, in utero DEHP exposure has been shown to alter sexual organ development, decrease testosterone and aldosterone production, increase body and epididymal adipose tissue weight, and raise serum lipids and glucose levels in male offspring.

Objectives

The objective of this study is to characterize the effects of in utero DEHP exposure on adipose tissue development and function in male offspring.

Methods

Sprague-Dawley pregnant dams were gavaged 1, 20, 50 or 300 mg DEHP per kg per day from gestational day 14

SUBMITTER: Campioli E 

PROVIDER: S-EPMC4042311 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature