Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection.

ABSTRACT:

Objective

Studies of neutralizing antibodies in HIV-1 infected individuals provide insights into the quality of the response that should be possible to elicit with vaccines and ways to design effective immunogens. Some individuals make high titres of exceptional broadly reactive neutralizing antibodies that are of particular interest; however, more modest responses may be a reasonable goal for vaccines. We performed a large cross-sectional study to determine the spectrum of neutralization potency and breadth that is seen during chronic HIV-1 infection.

Design

Neutralization potency and breadth were assessed with genetically and geographically diverse panels of 205 chronic HIV-1 sera and 219 Env-pseudotyped viruses representing all major genetic subtypes of HIV-1.

Methods<

SUBMITTER: Hraber P 

PROVIDER: S-EPMC4042313 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature