Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides.

ABSTRACT: We are environmentally exposed to countless synthetic chemicals on a daily basis, with an increasing number of these chemical exposures linked to adverse health effects. However, our understanding of the (patho)physiological effects of these chemicals remains poorly understood, due in part to a general lack of effort to systematically and comprehensively identify the direct interactions of environmental chemicals with biological macromolecules in mammalian systems in vivo. Here, we have used functional chemoproteomic and metabolomic platforms to broadly identify direct enzyme targets that are inhibited by widely used organophosphorus (OP) pesticides in vivo in mice and to determine metabolic alterations that are caused by these chemicals. We find that these pesticides directly inhibit over

SUBMITTER: Medina-Cleghorn D 

PROVIDER: S-EPMC4042408 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature