Copy number variants and selective sweeps in natural populations of the house mouse (Mus musculus domesticus).

ABSTRACT: Copy-number variants (CNVs) may play an important role in early adaptations, potentially facilitating rapid divergence of populations. We describe an approach to study this question by investigating CNVs present in natural populations of mice in the early stages of divergence and their involvement in selective sweeps. We have analyzed individuals from two recently diverged natural populations of the house mouse (Mus musculus domesticus) from Germany and France using custom, high-density, comparative genome hybridization arrays (CGH) that covered almost 164 Mb and 2444 genes. One thousand eight hundred and sixty one of those genes we previously identified as differentially expressed between these populations, while the expression of the remaining genes was invariant. In total, we identified

SUBMITTER: Bryk J 

PROVIDER: S-EPMC4042557 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature