Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.

ABSTRACT: There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show that the immunological responses induced by members of a broad class of inorganic crystalline materials are controlled purely by their physicochemical properties in a highly predictable manner. We show that structurally and chemically homogeneous layered double hydroxides (LDHs) can elicit diverse human dendritic cell responses in vitro. Using a systems vaccinology approach, we find that every measured response can be modeled using a subset of just three physical and chemical properties for all compounds tested. This correlation can be reduced to a simple linear equation that enables the immunological responses stimulated by newly synthesiz

SUBMITTER: Williams GR 

PROVIDER: S-EPMC4042647 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature