Increased glucose uptake in visceral versus subcutaneous adipose tissue revealed by PET imaging.

ABSTRACT:

Objectives

The current study tested the hypothesis that glucose utilization differs between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and investigated potential mechanisms for such a finding.

Background

VAT burden correlates better with cardiovascular risk than does SAT burden. Beyond volumetric measurement, glucose uptake in adipose tissue (AT) might reflect metabolic activity and provide pathophysiologic insight and aid risk stratification.

Methods

We retrospectively studied tissue-specific glucose uptake in vivo in clinically obtained whole-body fluorodeoxyglucose positron emission tomography (FDG-PET) scans in humans. We also assessed glucose uptake in vitro, using stromal vascular cells isolated from SAT and VAT of diet-induced obese C5

SUBMITTER: Christen T 

PROVIDER: S-EPMC4042675 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature