Conceptualization of molecular findings by mining gene annotations.

ABSTRACT:

Background

The Gene Ontology (GO) is an ontology representing molecular biology concepts related to genes and their products. Current annotations from the GO Consortium tend to be highly specific, and contemporary genome-scale studies often return a long list of genes of potential interest, such as genes in a cancer tumor that are differentially expressed than those found in normal tissue. It is therefore a challenging task to reveal, at a conceptual level, the major functional themes in which genes are involved. Presently, there is a need for tools capable of revealing such themes through mining and representing semantic information in an objective and quantitative manner.

Methods

In this study, we utilized the hierarchical organization of the GO to derive a more abstract r

SUBMITTER: Chen V 

PROVIDER: S-EPMC4042834 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature