Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.

ABSTRACT: The transcription factor Tbx5 is expressed in the developing heart, eyes and anterior appendages. Mutations in human TBX5 cause Holt-Oram syndrome, a condition characterized by heart and upper limb malformations. Tbx5-knockout mouse embryos have severely impaired forelimb and heart morphogenesis from the earliest stages of their development. However, zebrafish embryos with compromised tbx5 function show a complete absence of pectoral fins, while heart development is disturbed at significantly later developmental stages and eye development remains to be thoroughly analysed. We identified a novel tbx5 gene in zebrafish--tbx5b--that is co-expressed with its paralogue, tbx5a, in the developing eye and heart and hypothesized that functional redundancy could be occurring in these organs in embry

SUBMITTER: Pi-Roig A 

PROVIDER: S-EPMC4043114 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature