Waning of maternal antibodies against measles, mumps, rubella, and varicella in communities with contrasting vaccination coverage.

ABSTRACT:

Background

The combined measles, mumps, and rubella (MMR) vaccine has been successfully administered for >20 years. Because of this, protection by maternal antibodies in infants born to vaccinated mothers might be negatively affected.

Methods

 A large cross-sectional serologic survey was conducted in the Netherlands during 2006-2007. We compared the kinetics of antibody concentrations in children and women of childbearing age in the highly vaccinated general population with those in orthodox Protestant communities that were exposed to outbreaks.

Results

 The estimated duration of protection by maternal antibodies among infants in the general population, most of whom were born to vaccinated mothers, was short: 3.3 months for measles, 2.7 months for mumps, 3.9 months fo

SUBMITTER: Waaijenborg S 

PROVIDER: S-EPMC4043230 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature