Enhanced photoacoustic gas analyser response time and impact on accuracy at fast ventilation rates during multiple breath washout.

ABSTRACT:

Background

The Innocor device contains a highly sensitive photoacoustic gas analyser that has been used to perform multiple breath washout (MBW) measurements using very low concentrations of the tracer gas SF6. Use in smaller subjects has been restricted by the requirement for a gas analyser response time of <100 ms, in order to ensure accurate estimation of lung volumes at rapid ventilation rates.

Methods

A series of previously reported and novel enhancements were made to the gas analyser to produce a clinically practical system with a reduced response time. An enhanced lung model system, capable of delivering highly accurate ventilation rates and volumes, was used to assess in vitro accuracy of functional residual capacity (FRC) volume calculation and the effects of flow a

SUBMITTER: Horsley A 

PROVIDER: S-EPMC4043749 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature