Molecular characterizations of Nop16 in murine mammary tumors with varying levels of c-Myc.

ABSTRACT: NOP16, also known as HSPC111, has been identified as a MYC and estrogen regulated gene in in vitro studies, hence coexpression levels were strongly correlated. Importantly, high expression of NOP16 was associated with poor clinical outcome in breast cancer patients. However, coexpression of NOP16, MYC and estrogen receptor (ESR1) varied widely in tumors and cell lines suggesting that transcriptional regulation differed according to pathological environments. The goal of this study was to determine the expression patterns of Nop16, Myc and Esr1 in murine mammary tumors with disparate histopathological and molecular features. We hypothesized that tumor environments with relatively high Myc levels would have different coexpression patterns than tumor environments with relatively low Myc level

SUBMITTER: Kundel DW 

PROVIDER: S-EPMC4043839 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature