Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses.

ABSTRACT:

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The contribution of humoral immune responses to spontaneous control of hepatitis C virus (HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses during acute HCV infection to determine whether infection outcome is associated with the nAb response, specifically, its timing or breadth (neutralization of multiple genotype-matched variants). A representative genotype 1 HCV pseudoparticle (HCVpp) library, consisting of 19 genetically distinct genotype 1 HCVpp that comprise the natural variability of genotype 1 E1E2 sequences, was used to assess anti-genotype 1 nAb responses during acute infection in at-risk persons followed prospectively. Neutralization of individual library HCVpp by the last viremic plasma sample obtained before clearance was compa

SUBMITTER: Osburn WO 

PROVIDER: S-EPMC4043926 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature