PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.

ABSTRACT:

Background

Suspected coronary artery disease (CAD) is one of the most common, potentially life-threatening diagnostic problems clinicians encounter. However, no large outcome-based randomized trials have been performed to guide the selection of diagnostic strategies for these patients.

Methods

The PROMISE study is a prospective, randomized trial comparing the effectiveness of 2 initial diagnostic strategies in patients with symptoms suspicious for CAD. Patients are randomized to either (1) functional testing (exercise electrocardiogram, stress nuclear imaging, or stress echocardiogram) or (2) anatomical testing with ≥64-slice multidetector coronary computed tomographic angiography. Tests are interpreted locally in real time by subspecialty certified physicians, and all subse

SUBMITTER: Douglas PS 

PROVIDER: S-EPMC4044617 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature