Aneurysm-osteoarthritis syndrome with visceral and iliac artery aneurysms.

ABSTRACT:

Objective

Aneurysms-osteoarthritis syndrome (AOS), caused by SMAD3 mutations, is a recently described autosomal-dominant syndrome characterized by arterial aneurysms, tortuosity, and aortic dissections in combination with osteoarthritis. Our objective was to evaluate the AOS-related vascular consequences in the visceral and iliac arteries and raise awareness for this aggressive syndrome among vascular specialists.

Methods

All AOS patients were monitored regularly according to our clinical AOS protocol. The study included those with one or more visceral aneurysms or tortuosity, or both. Clinical and surgical data were obtained from record abstraction.

Results

The study included 17 AOS patients (47% men) aged 47±13 years. A total of 73 aneurysms were encountered, of whi

SUBMITTER: van der Linde D 

PROVIDER: S-EPMC4044827 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature