Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain.

ABSTRACT:

Objective

To determine the efficacy and safety of topical rubefacients containing salicylates in acute and chronic pain.

Data sources

Electronic databases and manufacturers of salicylates.

Study selection

Randomised double blind trials comparing topical rubefacients with placebo or another active treatment, in adults with acute or chronic pain, and reporting dichotomous information, around a 50% reduction in pain, and analyses at one week for acute conditions and two weeks for chronic conditions.

Data extraction

Relative benefit and number needed to treat, analysis of adverse events, and withdrawals.

Data synthesis

Three double blind placebo controlled trials had information on 182 patients with acute conditions. Topical salicylate was significantly bett

SUBMITTER: Mason L 

PROVIDER: S-EPMC404501 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature