Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells.

ABSTRACT: Dendritic cells (DCs) are the major sentinel, antigen-presenting and regulatory components of the immune system. One of the central DC functions is to rapidly sense and alert host immune system of a pathogen invasion. In the present study, we investigated the role of DC exosomes (DCex) in this sentinel function. We demonstrated that DCex could bind bacterial Toll-like-receptor ligands (TLR-Ls), and acquire their ability to strongly activate bystander DCs. Consequently, bystander DCs enhance the expression of transmembrane tumor necrosis factor, secretion of proinflammatory cytokines and cross-talk with natural killer cells leading to the elevated secretion of IFNγ. These findings newly show that DCex can bind and cross-present TLR-Ls to innate-immunity effector cells, and indicate a potent

SUBMITTER: Sobo-Vujanovic A 

PROVIDER: S-EPMC4045011 | biostudies-literature | 2014 May-Jun

REPOSITORIES: biostudies-literature