Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology.

ABSTRACT:

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To elucidate mechanisms underlying the complex relationships between a host and its microbiota, we used the genetically tractable model Drosophila melanogaster. Consistent with previous studies, the microbiota was simple in composition and diversity. However, analysis of single flies revealed high interfly variability that correlated with differences in feeding. To understand the effects of this simple and variable consortium, we compared the transcriptome of guts from conventionally reared flies to that for their axenically reared counterparts. Our analysis of two wild-type fly lines identified 121 up- and 31 downregulated genes. The majority of these genes were associated with immune responses, tissue homeostasis, gut physiology, and metabolism. By comparing the transc

SUBMITTER: Broderick NA 

PROVIDER: S-EPMC4045073 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature