Simulations to compare efficacies of tetravalent dengue vaccines and mosquito vector control.

ABSTRACT:

Summary

Infection with dengue, the most prevalent mosquito-borne virus, manifests as dengue fever (DF) or the more fatal dengue haemorrhagic fever (DHF). DHF occurs mainly when an individual who has acquired antibodies to one serotype is inoculated with another serotype. It was reported that mosquito control may have increased the incidence of DF and DHF due to age-dependency in manifesting these illnesses or an immunological mechanism. Tetravalent dengue vaccine is currently being tested in clinical trials. However, seroconversions to all four serotypes were achieved only after three doses. Therefore, vaccines may predispose vaccinees to the risk of developing DHF in future infections. This study employed an individual-based computer simulation, to emulate mosquito control and vac

SUBMITTER: Thavara U 

PROVIDER: S-EPMC4045171 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature