Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees.

ABSTRACT:

Importance

Genetic factors contribute to risk for bipolar disorder (BP), but its pathogenesis remains poorly understood. A focus on measuring multisystem quantitative traits that may be components of BP psychopathology may enable genetic dissection of this complex disorder, and investigation of extended pedigrees from genetically isolated populations may facilitate the detection of specific genetic variants that affect BP as well as its component phenotypes.

Objective

To identify quantitative neurocognitive, temperament-related, and neuroanatomical phenotypes that appear heritable and associated with severe BP (bipolar I disorder [BP-I]) and therefore suitable for genetic linkage and association studies aimed at identifying variants contributing to BP-I risk.

Design, sett

SUBMITTER: Fears SC 

PROVIDER: S-EPMC4045237 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature