Integrative analysis of transcriptional regulatory network and copy number variation in intrahepatic cholangiocarcinoma.

ABSTRACT:

Background

Transcriptional regulatory network (TRN) is used to study conditional regulatory relationships between transcriptional factors and genes. However few studies have tried to integrate genomic variation information such as copy number variation (CNV) with TRN to find causal disturbances in a network. Intrahepatic cholangiocarcinoma (ICC) is the second most common hepatic carcinoma with high malignancy and poor prognosis. Research about ICC is relatively limited comparing to hepatocellular carcinoma, and there are no approved gene therapeutic targets yet.

Method

We first constructed TRN of ICC (ICC-TRN) using forward-and-reverse combined engineering method, and then integrated copy number variation information with ICC-TRN to select CNV-related modules and constructed

SUBMITTER: Li L 

PROVIDER: S-EPMC4045758 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature