MP-Align: alignment of metabolic pathways.

ABSTRACT:

Background

Comparing the metabolic pathways of different species is useful for understanding metabolic functions and can help in studying diseases and engineering drugs. Several comparison techniques for metabolic pathways have been introduced in the literature as a first attempt in this direction. The approaches are based on some simplified representation of metabolic pathways and on a related definition of a similarity score (or distance measure) between two pathways. More recent comparative research focuses on alignment techniques that can identify similar parts between pathways.

Results

We propose a methodology for the pairwise comparison and alignment of metabolic pathways that aims at providing the largest conserved substructure of the pathways under consideration. The

SUBMITTER: Alberich R 

PROVIDER: S-EPMC4045882 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature